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Mitragynine Pseudoindoxyl Uses and Benefits

If you can’t pronounce mitragynine pseudoindoxyl, don’t worry—you’re not alone. In fact, we’re not sure anyone knows how to pronounce it at first glance! But what we can do is tell you what it does. Mitragynine pseudoindoxyl uses are varied, and though research into it is ongoing, the possibilities are exciting. 

You’d be forgiven if you weren’t exactly sure about the relationship this compound has to kratom, its forebear. We should probably begin by pulling back the veil of complicated science terminology. So, what the heck is this stuff, and why does it matter? 

What is Mitragynine Pseudoindoxyl?

hands holding leaves over bowl

Mitragynine pseudoindoxyl is basically the child of two loving parents—kratom and your metabolism. It’s a metabolite, which means it's a new substance that our bodies create while digesting something else. Kratom’s primary alkaloid, mitragynine, gets metabolized into mitragynine pseudoindoxyl and another alkaloid called 7-hydroxymitragynine (7-OH). 

It’s less researched and understood than its predecessors and fellow kratom metabolites, but no less promising. Mitragynine pseudoindoxyl interacts with opioid receptors to relieve pain but doesn’t come with the usual downsides of actual opioids. Let’s get into the nitty-gritty of this fascinating compound.  

Mitragynine Pseudoindoxyl Benefits: What Research Reveals

Mitragynine pseudoindoxyl is best known for pain relief, but research into its other benefits is limited. Because kratom has various alkaloids and metabolites working in harmony, it’s proven difficult to attribute specific benefits to specific compounds. 

That said, it’s safe to say that mitragynine pseudoindoxyl also plays a part in the additional benefits of kratom: euphoria, mental clarity, increased alertness, relaxation, and more. 

It’s been shown to relieve pain effectively without causing respiratory depression or physical dependency.  This alone makes it far more appealing than other opioid therapies available.

5 Potential Mitragynine Pseudoindoxyl Uses You Should Know

bunch of bright green leaves

Now that we’ve got a clearer picture of what this very sciency-sounding thing is, let’s talk about mitragynine pseudoindoxyl uses and effects. From dulling pain to sharpening focus, this metabolite could be what it takes to set your mind and body at ease. We’ll walk through all the relaxing and stimulating possibilities. 

1. Natural Pain Relief

As mentioned already, mitragynine pseudoindoxyl has powerful analgesic properties. Because it's a metabolite of mitragynine, it’s more potent than the alkaloid (which is already more potent than morphine!). 

You can use mitragynine pseudoindoxyl to alleviate muscle pain, joint discomfort, and more.

2. Mental Clarity & Focus

Kratom itself can be used as either a sedative or a stimulant, but with mitragynine pseudoindoxyl the stimulant effects win out. 

You can use it to enhance your alertness, motivation, and focus without becoming overstimulated. 

3. Mood Enhancer

A bit of joy never hurts. Mitragynine pseudoindoxyl can provide both emotional support and a mild euphoric state.

This boost can come both directly and indirectly. Dopamine and serotonin levels are affected by kratom, but the ripple effect of pain relief and a clear mind also contributes to this mood boost. 

4. Stress Relief

Though it is a stimulant, mitragynine pseudoindoxyl still promotes a calm and balanced mental state. The soothing nature of its effects helps users relax without feeling sleepy. 

5. Opioid Alternative & Opioid Withdrawal

For someone dealing with opioid withdrawal or someone who simply wishes to avoid opioids altogether, mitragynine pseudoindoxyl is an attractive option. It’s stronger than morphine but doesn’t come paired with such serious side effects as a high risk of dependence. 

That said, it’s important to note that it hasn’t been approved for treating opioid use disorder. It’s not a miracle drug, but it could be a good option to help bridge the near-unbridgeable gap left by opioids. 

When Should I Avoid Using Mitragynine Pseudoindoxyl?

Kratom and its associated alkaloids and metabolites aren’t without their downsides. We’ll get into the potential side effects in a second, but first, let’s talk about who shouldn’t use mitragynine pseudoindoxyl. 

If you’re pregnant or nursing, it’s best to avoid using mitragynine pseudoindoxyl and kratom in general. The same goes for anyone under 21 years of age, and especially those with medical conditions. Always, always, always check with your doctor before trying any new health supplement. 

Here are the potential side effects of mitragynine pseudoindoxyl: 

  • Nausea
  • Vomiting
  • Constipation
  • Insomnia
  • Irritability

Pro Tips for Using Mitragynine Pseudoindoxyl Safely

woman holding up green capsules

Now, let’s assume you’re new to the mitragynine pseudoindoxyl game and want to learn the ins and outs. What should you take, how should you take it, and what’s going to work best for you? Ultimately, only you can really answer those questions, but we’ll try to point you in the right direction to find the answers. 

To get the most out of pain-relieving effects and general boosts to physical and mental wellness, here are a few tips you should keep in mind. 

  • Start low and go slow. Trust us here. Start with a low dose and slowly work your way up from there. Once you find the lowest effective dose for your body and needs, you’ll be glad you didn’t accidentally start too high. Capsules and tablets are a simple, straightforward place to start. Powders and extracts are more flexible and can be used to customize dosages and effects. 
  • Take notes. This might sound like useless homework, but it’s the opposite. As you try different products, dosages, and combinations thereof, jot down notes of how they affected your physical state (for example, pain reduction), energy levels, and mental state.
  • Research and try different kratom products. Maybe mitragynine pseudoindoxyl is what you need, or maybe it isn’t. Kratom in its natural state could be better, or another alkaloid like 7-OH. Finding the right balance and supplement for your health goals will take time and some experimentation. 
  • Check with your doctor first. Make sure you’re not at risk of any severe side effects of kratom and its alkaloids before trying them. In extreme cases, hallucinations, seizures, and even delusions can occur. 

Explore Mitragynine Pseudoindoxyl Products at Gold Dragon

When you’re ready to give mitragynine pseudoindoxyl a shot, Gold Dragon is ready to get you started. Shop our collection of pseudoindoxyl-only products today. Natural pain relief, relaxation, and a wholly improved mood are just a few clicks away. 


Need some help finding just the right thing for your wellness goals? Click here for a free consultation, day or night. Our team has your back, and will happily answer any questions you may have.

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Brie Lowrey

Brie Lowrey, Gold Dragon ECommerce Director, is a Kansas City Native now residing in Colorado. She thrives on keeping up with mountain biking, brewery hopping, and sending out office-wide dragon jokes. Connect with her on LinkedIn and Instagram.

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