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It is important to realize that kratom can be addictive, and can itself create severe withdrawal symptoms. Side effects might include:

·   Weight loss

·   Fatigue

·   Constipation

·   Insomnia

·   Dry mouth

·   Frequent urination

·   Hyperpigmentation of the cheeks

·   Tremors/seizures

·   Psychosis

Despite this, toxicity of kratom is considered to be relatively mild. One of the primary safety concerns is drug-drug interactions with other recreational substances or medications.

Kratom is an herbal substance that’s believed to produce stimulant- and opioid-like effects, depending on how much you consume. The kratom you might find in stores is usually sold as a supplement that may claim to boost energy, improve your mood, and relieve pain.

Kratom is now legal in most of the US, though a few exceptions remain. While this accessibility benefits those with chronic pain, the lack of regulation highlights the need to research and buy from reputable sources. Verify its legality in your state and locality before purchase, as some cities may have additional restrictions (e.g., San Diego).

Kratom can take effect within five to ten minutes after ingestion. Effects can be expected to last for five to seven hours, with the effects peaking at about two to four hours. However, mild effects may last even into the next day.

The two most potent alkaloids in kratom have half-lives of 2.5-3.5 hours. That means that it takes about three hours for the concentration of the alkaloid in the body to be reduced by one-half. The active compounds are eliminated through the urine.

Consuming kratom with food may delay the onset of the effects. There are also other ways to enhance extraction of the bioactive alkaloids, or enhance absorption of alkaloids in the small intestine. That is why different modes of consumption (for example, kratom capsules, tablets, or teas) can change the way you experience kratom.